This website is intended for a European audience and is made available by Amgen.
Neuromyelitis optica spectrum disorder (NMOSD) is a rare and debilitating autoimmune
disease
driven by
severe, recurrent central nervous system (CNS) attacks which can result in
blindness,
paralysis, and death.1
Globally, NMOSD affects approximately 0.5-4 in every 100,000 people.2,3
Over 10,000 of these people live in Europe.4
Median age of disease onset is 40.5
Women are 9x more likely to be impacted than men.6
75% of seropositive patients with NMOSD may experience pain.7
41% of seropositive patients with NMOSD may become legally blind in at least one eye 5 years after disease onset.8
41% of patients have also reported an initial misdiagnosis of MS (multiple sclerosis).9
Historically, NMOSD was often misdiagnosed or missed due to its similarities with other conditions, such as MS.10 However, the two diseases are distinct and NMOSD is a condition in its own right. It has a very different clinical and patient trajectory, along with outcomes and management strategies.
People impacted by NMOSD live with unpredictable attacks, 90% are likely to have repeated attacks within five years of an initial attack.11
Unlike other autoimmune diseases, individuals with NMOSD often do not fully recover from attacks, and permanent disability results from accumulating damage attacks.12
NMOSD |
MS |
---|---|
Key symptom: Severe vision impairment |
Key symptoms: Fatigue & cognitive impairment (incl. information processing speed & attention)17 |
Severe acute episodes can lead to permanent disability | Progressive disability caused by individual, typically mild, episodes |
Permanent CNS damage | Often experience better recovery from attacks |
AQP4 antibody seropositive* | AQP4 antibody seronegative |
* 80% of people with NMOSD are AQP4 antibody seropositive, but people with MS are always seronegative.12,18
Differential diagnosis of NMOSD and MS treatment may be ineffective against, or may even exacerbate NMOSD.19
AQP4-IgG serology is a confirmatory diagnostic for NMOSD.20,21
A cell-based assay is the most reliable test and highly recommended.20,22